Respiratory Monitoring & Control

Modeling, monitoring and control of respiratory support

Breathing is a process most of us take for granted, and its failure is a medical emergency. Providing personalized respiratory support is a huge challenge: Every patient has different metabolic needs, different respiratory anatomy and physiology, and a different natural breathing rhythm. Studies have shown that many patients are not ventilated in a way that supports their natural respiratory rhythm, potentially leading to grave consequences ranging from patient trauma due to a loss of autonomy over one’s own respiration over severe lung injury to death.

Our vision is a mechanical ventilator that…

  1. Monitors a patient’s own respiratory activity during mechanical ventilation,
  2. Identifies a model of the patient’s respiratory system, and
  3. Uses this information to optimally align ventilator support with the patient’s needs by using advanced control techniques.

More specifically, we…

  • Apply advanced signal processing techniques to measurement modalities such as camera signals, respiratory surface EMG measurements and esophageal pressure measurements to obtain reliable measurements of respiratory activity.
  • Model all aspects of the respiratory system, including respiratory mechanics and lung properties, gas exchange, and respiratory control mechanisms.
  • Use modern control techniques such as model-predictive control (MPC) to design advanced ventilator control schemes based on these models and measurements.

Key Publications

2020

  • Petersen, Eike and Graßhoff, Jan and Eger, Marcus and Rostalski, Philipp: Surface EMG-based Estimation of Breathing Effort for Neurally Adjusted Ventilation Control. in Proceedings of the 21st IFAC World Congress, 2020
    BibTeX
    @inproceedings{PeGrEgRo20,
      author    = {Petersen, Eike and Graßhoff, Jan and Eger, Marcus and Rostalski, Philipp},
      booktitle = {{Proceedings of the 21st IFAC World Congress}},
      title     = {Surface {EMG}-based Estimation of Breathing Effort for Neurally Adjusted Ventilation Control},
      year      = {2020}
    }
  • Jan Graßhoff and Philipp Rostalski: Spatio-Temporal Gaussian Processes for Separation of Ventilation and Perfusion Related Signals in EIT Data. in Proc. Workshop Automed, 2020
    BibTeX
    @inproceedings{GrRo20,
    author = {Jan Graßhoff and Philipp Rostalski},
    title = {Spatio-Temporal Gaussian Processes for Separation of Ventilation and Perfusion Related Signals in EIT Data},
    year = {2020},
    booktitle = {Proc. Workshop Automed}
    }
  • Graßhoff, Jan and Jankowski, Alexandra and Rostalski, Philipp: Scalable Gaussian Process Separation for Kernels with a Non-Stationary Phase. in Proceedings of the 37th International Conference on International Conference on Machine Learning (ICML), 2020
    BibTeX
    @inproceedings{GrJaRo20,
    author = {Graßhoff, Jan and Jankowski, Alexandra and Rostalski, Philipp},
    title = {Scalable Gaussian Process Separation for Kernels with a Non-Stationary Phase},
    booktitle = {Proceedings of the 37th International Conference on International Conference on Machine Learning (ICML)},
    year = {2020}
    }
    
  • Petersen, Eike and Sauer, Julia and Graßhoff, Jan and Rostalski, Philipp: Removing Cardiac Artifacts From Single-Channel Respiratory Electromyograms. IEEE Access, no. 8, pp. 30905-30917, Institute of Electrical and Electronics Engineers (IEEE), 2020
    BibTeX
    @Article{PeSaGrRo20,
      author    = {Petersen, Eike and Sauer, Julia and Graßhoff, Jan and Rostalski, Philipp},
      title     = {Removing Cardiac Artifacts From Single-Channel Respiratory Electromyograms},
      journal   = {{IEEE} Access},
      year      = {2020},
      volume    = {8},
      pages     = {30905--30917},
      doi       = {10.1109/access.2020.2972731},
      groups    = {ECG Removal from EMG recordings},
      publisher = {Institute of Electrical and Electronics Engineers ({IEEE})}
    }
  • Hermann, Juliane and Brehmer, Kai and Mahfoud, Felix and Speer, Timotheus and Schunk, Stefan J. and Tscherning, Thomas and Thiele, Herbert and Jankowski, Joachim: Registration of Image Modalities for Analyses of Tissue Samples using 3D Image Modelling. PROTEOMICS - Clinical Applications, Wiley, 2020
    BibTeX
    @article{HeBr20,
      title={Registration of Image Modalities for Analyses of Tissue Samples using 3D Image Modelling},
      author={Hermann, Juliane and Brehmer, Kai and Mahfoud, Felix and Speer, Timotheus and Schunk, Stefan J. and Tscherning, Thomas and Thiele, Herbert and Jankowski, Joachim},
      journal={PROTEOMICS -- Clinical Applications},
      year={2020},
      publisher={Wiley},
    }
  • Abbas, Hossam S. and Graßhoff, Jan and Rostalski, P. and Brinkmann, R.: On the Estimation of Optoacoustic Waves in Retinal Laser Therapy Using Gaussian Processes. in Proc. Workshop Automed, Lübeck, Germany, March, 2020
    BibTeX
    @INPROCEEDINGS{AbGrRoBr20, 
    author={Abbas, Hossam S. and Graßhoff, Jan and Rostalski, P. and Brinkmann, R.}, 
    booktitle={Proc. Workshop Automed}, 
    title={{On the Estimation of Optoacoustic Waves in Retinal Laser Therapy Using Gaussian Processes}}, 
    year={2020},  
    pages={}, 
    address={Lübeck, Germany},
    month={March}
    }

2019

  • Niclas Bockelmann and Jan Graßhoff and Lasse Hansen and Mattias Heinrich and Philipp Rostalski: Deep Learning for Prediction of Diaphragm Activity from the Surface Electromyogram. in Directions in Biomedical Engineering, no. 5, pp. 17-20, De Gruyter, 2019
    BibTeX
    @inproceedings{BoGrHaHeRo19,
      author    = {Niclas Bockelmann and Jan Graßhoff and Lasse Hansen and Mattias Heinrich and Philipp Rostalski},
      title     = {Deep Learning for Prediction of Diaphragm Activity from the Surface Electromyogram},
      booktitle = {Directions in Biomedical Engineering},
      year      = {2019},
      publisher = {De Gruyter},
      pages     = {17--20},
      volume    = {5},
      number    = {1}
    }
  • J. Graßhoff and E. Petersen and T. Becher and P. Rostalski: Automatic Estimation of Respiratory Effort using Esophageal Pressure. in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 4646-4649, July, 2019
    BibTeX
    @inproceedings{GrPeBeRo19,
    author={J. {Graßhoff} and E. {Petersen} and T. {Becher} and P. {Rostalski}},
    booktitle={2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)},
    title={Automatic Estimation of Respiratory Effort using Esophageal Pressure},
    year={2019},
    pages={4646-4649},
    doi={10.1109/EMBC.2019.8856345},
    ISSN={1557-170X},
    month={July}}

2018

  • Olbrich, Michael and Petersen, Eike and Hoffmann, Christian and Rostalski, Philipp: Sparse Estimation for the Assessment of Muscular Activity based on sEMG Measurements. in Proc. 18th Symp. Syst. Ident., 2018
    BibTeX
    @inproceedings{OlPeHoRo18,
     author = {Olbrich, Michael and Petersen, Eike and Hoffmann, Christian and Rostalski, Philipp},
     abstract = {},
     title = {{Sparse Estimation for the Assessment of Muscular Activity based on sEMG Measurements}},
     year = {2018},
     booktitle = {Proc. 18th Symp. Syst. Ident.}
    }

2017

  • Petersen, Eike and Buchner, Herbert and Eger, Marcus and Rostalski, Philipp: Convolutive blind source separation of surface EMG measurements of the respiratory muscles. Biomed. Tech., no. 62, pp. 171-181, 2017
    BibTeX
    @article{PeBuEgRo17,
     author = {Petersen, Eike and Buchner, Herbert and Eger, Marcus and Rostalski, Philipp},
     year = {2017},
     title = {{Convolutive blind source separation of surface EMG measurements of the respiratory muscles}},
     pages = {171--181},
     volume = {62},
     number = {2},
     journal = {Biomed. Tech.} 
    }
  • Graßhoff, Jan and Petersen, Eike and Eger, Marcus and Bellani, Giacomo and Rostalski, Philipp: A Template Subtraction Method for the Removal of Cardiogenic Oscillations on Esophageal Pressure Signals. in Proc. 39th Ann. Int. Conf. Eng. Med. Biol. Soc., 2017
    BibTeX
    @inproceedings{GrPeEgBe17,
     author = {Graßhoff, Jan and Petersen, Eike and Eger, Marcus and Bellani, Giacomo and Rostalski, Philipp},
     title = {{A Template Subtraction Method for the Removal of Cardiogenic Oscillations on Esophageal Pressure Signals}},
     year = {2017},
     booktitle = {Proc. 39th Ann. Int. Conf. Eng. Med. Biol. Soc.}
    }